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Abstract #1624

3D whole-heart free-breathing joint T1/T2 mapping with isotropic resolution in a hybrid PET-MR system for cardiac sarcoidosis

Alina Schneider1, Michael G Crabb1, Carlos Velasco1, Karl P Kunze1,2, Radhouene Neji1,2, René M Botnar1,3, and Claudia Prieto1,3
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 3Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

Synopsis

Keywords: Quantitative Imaging, CardiovascularSimultaneously acquired 18F-FDG PET-MR imaging and quantitative 2D T1 and T2 mapping have been suggested for improved diagnostic accuracy of cardiac sarcoidosis, however misregistration between imaging modalities and sequential MR scans makes clinical interpretation challenging. Here we evaluate the feasibility of recently proposed 3D joint T1/T2 sequence at a 3T PET-MR system. This approach enables non-rigid motion-correction for both the 3D T1/T2 mapping and the PET data to the same respiratory position, resulting in aligned volumes for improved clinical interpretation. In this proof-of-concept study, we tested our approach in a phantom and two healthy subjects.

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