Abstract #1636

Comparison of synthesized and acquired high b-value diffusion-weighted MRI for detection of prostate cancer

Karoline Kallis¹, Christopher C. Conlin², Troy S. Hussain¹, Allison Y. Zhong¹, Deoandre Do¹, Asona J. Lui¹, Roshan Karunamuni², Joshua Kuperman², Michael E. Hahn², Rebecca Rakow-Penner², Aritrick Chatterjee^3,4, Aytekin Oto^3,4, Gregory S. Karczmar^3,4, Anders M. Dale^5,6,7, and Tyler M. Seibert^2,8,9

¹Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, United States, ²Department of Radiology, University of California San Diego, La Jolla, CA, United States, ³Department of Radiology, University of Chicago, Chicago, IL, United States, ⁴Sanford J. Grossmann Center of Excellence in Prostate Imaging and Image Guided Therapy, University of Chicago, Chicago, IL, United States, ⁵Department of Radiology, University of California San Diego, San Diego, CA, United States, ⁶Department of Neurosciences, University of California, La Jolla, CA, United States, ⁷Halicioglu Data Science Institute, University of California San Diego, La Jolla, CA, United States, ⁸Department of Radiation Medicine and Applied Sciences, University of California San Diego, San Diego, CA, United States, ⁹Department of Bioengineering, University of California San Diego, La Jolla, CA, United States

Synopsis

Keywords: Quantitative Imaging, Diffusion/other diffusion imaging techniquesHigh b-value diffusion-weighted imaging (DWI) plays an important role for accurate detection of clinically significant prostate cancer (csPCa). Synthesizing high b-value images decreases scan time. We compared (normalized) acquired and synthesized high b-value (2000s/mm²) DWI for detection of csPCa in 151 patients who underwent MRI and biopsy. We also compared these to an advanced DWI biomarker called the Restriction Spectrum Imaging restriction score (RSIrs). Synthesized images yielded similar results to acquired images within the prostate but failed to accurately represent the surrounding pelvic tissue. RSIrs was superior to synthesized and acquired high b-value DWI for detection of csPCa.

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