Keywords: Cancer, Elastography, Hepatocellular carcinomaA histologic sign known as “vessels encapsulating tumor clusters” (VETC) has been shown to be a powerful predictor of aggressive hepatocellular carcinoma (HCC) and is associated with unfavorable prognosis. It has been previously demonstrated that MR elastography (MRE)-based stiffness and shear strain mapping are promising in prediction of HCC aggressiveness. We investigated the diagnostic performance of MRE for predicting the VETC finding in HCC. Our results showed that 3D MRE-based peritumor OSS-pLSL and tumor stiffness performed well in predicting VETC status preoperatively, and their combination achieved an AUC of 0.92 in predicting VETC with sensitivity (87.9%) and specificity (83.9%).
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