Keywords: Cancer, Non-Proton, lymphedema, fibrosis, sodium, inflammation, adipose, lymph
Advanced-stage lymphedema is a disease of chronic fluid accumulation and tissue inflammation that results in fibrosis and subcutaneous fat expansion in affected limbs. Assessment of fat and fibrosis currently relies on biopsies or non-specific bedside measures. Noninvasive MRI could be important for understanding pathophysiology and evaluating emerging therapies. We cross-sectionally evaluated multi-nuclear proton and sodium MRI in patients with lower-extremity secondary lymphedema. Results reveal subcutaneous adipose tissue expansion throughout the affected calf, locoregional fibrosis, and elevated sodium content in fibroadipose tissues particularly in the anterior calf, thereby highlighting the relevance of these technologies for interrogating tissue health in lymphedema.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords