Abstract #1704

Assessment of Glx and GABA levels in primary dysmenorrhea patients in menstruation and periovulatory phases

Xue Chen¹, Zhou Huang¹, Peng Wu², and Yonggang Li^1,3,4

¹Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China, ²Philips Healthcare, Shanghai, China, ³Institute of Medical Imaging, Soochow University, Suzhou, China, ⁴National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China

Synopsis

Keywords: Nerves, BrainThe pathogenesis of primary dysmenorrhea (PDM) and the central nervous system (CNS) mechanisms leading to poorer mode and pain sensitization remain totally unclear, which was explored in our study using MEGA-PRESS. PDM patients showed significantly higher Glx level and mildly higher GABA+ level (not significantly) in ACC in menstruation phase. In menstruation phase, the SDS/PCS scores of the PDM patients had a positive correlation with ACC GABA+ levels. The imbalances in ACC GABA+/Glx levels in PDM patients in menstruation phase may be the mechanism mediating depressive symptoms and pain catastrophe.

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