Abstract #1706

A longitudinal neuroimaging study in mice on the effects of chronic high altitude exposure and repetitive traumatic brain injury

Alexandru Korotcov^1,2, Caroline A Browne^2,3, Asamoah Bosomtwi^1,4, Shalini Jaiswal^1,2, Nathan Cramer^2,5,6, Xiufen Xu^2,6, Kathleen Whiting^2,7, Cheryl D Stimpson^2,8, Bernard J Dardzinski^1,9, Daniel Perl⁸, Dara L Dickstein^2,8, and Zygmunt Galdzicki⁶

¹Department of Radiology and Radiological Sciences, Uniformed Services University, Bethesda, MD, United States, ²The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States, ³Department of Pharmacology and Molecular Therapeutics, Uniformed Service University, Bethesda, MD, United States, ⁴Georgia Cancer Center, Augusta University, Augusta, GA, United States, ⁵Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, United States, ⁶Department of Anatomy, Physiology and Genetics, Uniformed Service University, Bethesda, MD, United States, ⁷Graduate Program in Neuroscience, Uniformed Service University, Bethesda, MD, United States, ⁸Department of Pathology, Uniformed Service University, Bethesda, MD, United States, ⁹National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, United States

Synopsis

Keywords: Traumatic brain injury, Preclinical, hypobaria, hypoxia, DTI, PET/CT, cerebral blood flowChronic exposure to high altitude (HA) can lead to maladaptive physiological and pathological changes, resulting in an increased risk for neurological impairment. Whether the occurrence of mild traumatic brain injury (mTBI) at HA exacerbates neurobehavioral deficits remains uncertain. A series of experiments was conducted to test the impact of mTBI in the context of HA using established models of repetitive close head injury and simulated HA (5000m). A longitudinal study design was applied to identify the effects of chronic HA exposure (12 weeks) and mTBI in mice on neurobehavioral and neuroimaging biomarkers using PET and MRI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.