Abstract #1714

Altered resting state functional connectivity in high-contact sports

Mahta Karimpoor¹, Marios Georgiadis¹, Brian Mills¹, Hossein Moein Taghavi¹, Narvin Phouksouvath¹, Maged Goubran², Nicole Mouchawar¹, Sohrab Sami¹, Max Wintermark¹, Charles Liu³, John Van Horn⁴, Gerald Grant⁵, David Camarillo⁶, and Michael Zeineh¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Neurological Surgery, University of Southern California, Los Angeles, CA, United States, ⁴Psychology, University of Virginia, Charlottesville, VA, United States, ⁵Neurosurgery, Stanford University, Stanford, CA, United States, ⁶Bioengineering, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Traumatic brain injury, Brain Connectivity, high-contact sports, resting state functional connectivityRepetitive head impact exposure during contact sports may increase risk of cognitive decline and neurodegenerative disease. We compared resting state functional connectivity (rsFC) networks between a group of high-contact collegiate PAC-12 athletes and a low-contact group from two institutions (groups comprised athletes of multiple sports and both sexes). A community chi-squared analysis evaluated differences in connectivity within/between 12 brain networks comparing high- vs. low-contact sports. Across both institutions, rsFC in the high-contact cohort was significantly increased (hyperconnectivity) between dorsal attention and default mode network (DMN), and significantly decreased (hypoconnectivity) between dorsal attention and frontoparietal networks, compared to the low-contact cohort.

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