Keywords: Psychiatric Disorders, Spectroscopy, Oxidative StressOxidative stress is implicated in multiple psychiatric and neurodegenerative conditions, differs by biological sex and covaries with circulating estrogens. However, limited knowledge exists on the association of brain markers of oxidative stress via glutathione (GSH) with circulating sex hormones. Therefore, we conducted brain magnetic resonance spectroscopy, assayed blood serum for circulating sex hormones, and measured brain GSH-sex hormones associations. We found that dorsolateral prefrontal cortex GSH relates to estradiol in women and men and anterior cingulate cortex GSH relates to estradiol, estrone, and total testosterone in women. This study highlights the importance of considering sex in GSH MRS studies.
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