Keywords: Neuroinflammation, Brain ConnectivityThe goal of this study was to investigate the underlying mechanisms of suicidal behavior by detecting the dynamic functional connectivity (dFC) variability of hippocampus and HPA axis activity, as well as their relationship with personality traits in BD with suicidal attempt (SA). We assessed the activity of the HPA axis by measuring morning plasma adrenocorticotropic hormone (ACTH) and cortisol (CORT) levels. All participants underwent personality assessment using Minnesota Multiphasic Personality Inventory-2. BD with SA exhibited increased dFC variability of the hippocampal-temporal cortex and less HPA axis hyperactivity, which may both together lead to the possibility of changes in personality traits.
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