Abstract #1721

Interaction of Alzheimer’s Disease Status and History of Traumatic Brain Injury on Measures of Cortical Thickness

Gina D'Souza^1,2, Nathan W. Churchill^2,3,4, Dylan X. Guan⁵, Marc A. Khoury^1,2, Corinne E. Fischer^1,2,6, and Tom A. Schweizer^1,2,3,7,8

¹Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ²Keenan Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada, ³Neuroscience Research Program, St Michael's Hospital, Toronto, ON, Canada, ⁴Physics Department, Toronto Metropolitan University, Toronto, ON, Canada, ⁵Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁶Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, ⁷Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, ⁸The Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Alzheimer's Disease, Traumatic brain injuryTraumatic Brain Injury (TBI) is associated with an accelerated course of dementia, although biological relationships are still incompletely understood. We characterized the differences in cortical thickness, for Alzheimer’s Disease (AD) patients with and without a history of TBI. Among individuals diagnosed with AD, a history of TBI was associated with a smaller decrease in cortical thickness in frontal-temporal regions, relative to their non-AD counterparts, with analyses controlling for the effects of age, sex, and education. TBI may lower the susceptibility threshold for cognitive decline related to AD by decreasing an individuals’ ability to cope with aging and/or AD pathology.

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