Abstract #1724

White Matter Alterations Evident with DTI, DKI and Axonal Radius Measurements in Clinical Presentation of Chronic Symptomatic mTBI

Nastaren Abad¹, Chitresh Bhushan¹, Luca Marinelli¹, Afis Ajala¹, H. Doug Morris², Ante Zhu¹, Eric Fiveland¹, Seung-Kyun Lee¹, J Kevin DeMarco^2,3, Robert Shih^2,3, Maureen Hood^2,3, Gail Kohls³, Kimbra Kenney², Vincent Ho², and Thomas K.F Foo^1,2

¹GE Research, Niskayuna, NY, United States, ²Uniformed Services University of the Health Sciences, Bethesda, MD, United States, ³Walter Reed National Military Medical Center, Bethesda, MD, United States

Synopsis

Keywords: Traumatic brain injury, Diffusion/other diffusion imaging techniquesDiffusion MRI based microstructural evaluation of DTI, DKI, and intra-axonal radii, enabled by the ultra-high performance MAGNUS gradients, was leveraged in this study to assess differences between healthy controls and chronic mild traumatic brain injury presentations. Parcel-wise group and brain WM asymmetry analysis highlighted specific sub-region involvement differing from healthy controls in evaluated metrics. Subject specific analysis highlighted specific anatomical regions that could be more susceptible in TBI with the effect size potentially masked with central tendency analysis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.