Keywords: Neurodegeneration, fMRI (resting state)This is the first study on alterations in the patterns of dynamic functional connection density (dFCD) involving ALS. We obtained resting-state fMRI data from ALS and healthy controls (HCs). We calculated the functional connectivity (FC) and the functional connection density (FCD) value. dFCD was assessed by sliding-window correlation method. The standard deviation of dFCD can measure dFCD variability. The dFCD variability was reduced in some brain region in HC group, whereas increase was observed in some brain region of ALS patients. dFCD variability can distinguish two groups. ALS patients exhibit aberrant dynamic property in brain functional architecture.
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