Keywords: Neurodegeneration, fMRI (resting state)Amplitude of low-frequency fluctuation (ALFF) can identify abnormal regional neural activity in minimal hepatic encephalopathy (MHE). This work sought to evaluate the temporal variability of ALFF to reveal MHE-related alterations in the dynamics of spontaneous neural activity. Healthy controls and patients with cirrhosis [including MHE and without MHE (NHE)] were enrolled in this investigation. Utilizing a sliding-window approach to calculate the dynamic ALFF (dALFF) variability. The dALFF variability in some brain region progressively decreased from NHE to MHE group and it can distinguish NHE and MHE patients. Our findings highlight aberrant dynamic brain function in MHE.
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