Abstract #1733

Modiﬁcations of Large-Scale Resting-State Functional Connectivity in Spinocerebellar Ataxia Type 3

Bing LIU^1,2, Linwei Zhang³, Aocai Yang¹, Jixin Luan¹, Kuan Lv¹, and Guolin Ma¹

¹Department of Radiology, China Japan Friendship Hospital, Beijing, China, ²Graduate School of Peking Union Medical College, Beijing, China, ³Department of Neurology, China Japan Friendship Hospital, Beijing, China

Synopsis

Keywords: Neurodegeneration, Brain Connectivity, functional MRI, independent component analysis, spinocerebellar ataxia type 3, large-scale brain networks, functional connectivityLarge-scale resting-state functional network connectivity changes in spinocerebellar ataxia type 3 patients were found in both inter- and intranetwork functional connectivity. Especially, the increased intranetwork functional connectivity within the lateral visual network may potentially be a compensatory mechanism of visual-related symptoms in SCA3.

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