Abstract #1734

Mapping of neurodegenerative changes with Diffusion Tensor Imaging of Spinocerebellar ataxia type 1, 2 and 12 patients

Pankaj Pankaj¹, S Senthil Kumaran¹, Achal Kumar Srivastava², Ramesh Kumar Agrawal³, Ajay Garg⁴, Ashima Nehra⁵, and Roopa Rajan²

¹Nuclear Magnetic Resonance, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ²Neurology, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ³School of Computer & Systems Sciences, Jawaharlal Nehru University, New Delhi- 110 067, New Delhi, India, ⁴Neuro-radiology, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ⁵Neuropsychology, All India Institute of Medical Sciences, New Delhi, New Delhi, India

Synopsis

Keywords: Neurodegeneration, Diffusion Tensor ImagingThe study assessed changes in brain tissue microstructures in SCA type 1, 2 and 12 patients using diffusion tensor imaging. Our findings exhibited widespread reduced fractional anisotropy (FA), increased radial (RD) and axial diffusivity (AD) in SCA with respect to that in healthy subjects. FA was decreased in SCA1 and SCA2 in the superior and inferior longitudinal fasciculus, anterior thalamic radiation, inferior fronto-occipital fasiculus, forceps minor, corticospinal tract, cingulum, uncinate fasciculus as compared to controls. Abnormal white matter structure may be linked to cognitive and behavioural impairment in SCA 1 and SCA 2 patients.

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