Abstract #1735

Quantitative Susceptibility Mapping of cortical and subcortical brain regions in patients with REM sleep Behavior Disorder

Cristiana Fiscone¹, Fiorina Bartiromo², Luca Baldelli¹, Luisa Sambati³, Serena D'Aniello⁴, Stefania Evangelisti¹, Micaela Mitolo^2,5, Claudia Testa^2,6, Pietro Cortelli^1,3, Raffaele Lodi^1,2, Federica Provini^1,3, and Caterina Tonon^1,2

¹Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, ²Functional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, ³Clinica Neurologica Rete Metropolitana, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, ⁴Department of Advanced Biomedical Sciences, University of Naples Federico II, Napoli, Italy, ⁵Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy, ⁶Department of Physics and Astronomy, University of Bologna, Bologna, Italy

Synopsis

Keywords: Neurodegeneration, Brain, RBDREM sleep Behavior Disoder (RBD) is a parasomnia, possibly converting in a neurodegenerative α-synucleinopathy. We explored to role of iron accumulation in this condition exploiting Quantitative Susceptibility Mapping (QSM), a quantitative imaging technique returning susceptibility values voxel-per-voxel. RBD patients were compared to healthy controls; cortical and sub-cortical areas were segmented with automatic and semi-automatic methods and susceptibility distributions were compared. Significant increase of iron deposition resulted in multiple cortical areas, in the brainstem and in the gray matter nuclei of the limbic system, suggesting that QSM may help in identifying biomarkers that predict the conversion from RBD to neurodegeneration.

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