Abstract #1736

Free Water Imaging in deep gray matter nucleus of Wilson’s Disease

Xiao-Zhong Jing¹, Gai-Ying Li², Yu-Peng Wu³, Xiang-Zhen Yuan⁴, Jia-Lin Chen², Reyisha Taximaimaiti¹, Jian-Qi Li², and Xiao-Ping Wang⁵

¹Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, ³East China Normal University, Shanghai, China, ⁴Department of Neurology, Weifang People's Hospital, Weifang, China, ⁵Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

Keywords: Neurodegeneration, Diffusion/other diffusion imaging techniques, Wilson’s disease; free water imaging; quantitative susceptibility mapping.This is the first study to use a bi-tensor free water imaging to evaluate microstructural changes in deep gray matter (DGM) nuclei of Wilson’s disease (WD). Despite the shortcomings our study manifested that free water imaging detects microstructural alterations in both normal and abnormal appearing DGM nuclei of WD patients. Correlations between free water imaging indices and neurological impairment in WD patients were also noticed. Therefore, as a promising tool, free water imaging deserves further investigation in longitudinal studies to evaluate its role in monitoring disease onset, progression, and treatment efficacy in WD patients.

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