Abstract #1739

Structural waste clearance markers in the elderly: sex differences in the relation between perivascular and parasagittal dural space volume

Merel M. van der Thiel^1,2,3, Kilian Hett⁴, Nathalie A. Roos^1,5, Colin D. Mcknight⁶, Melanie K. Leguizamon⁴, Sofia Venturini^1,7, Inez H.G.B. Ramakers^3,8, Walter H. Backes^1,2,9, and Jacobus F.A. Jansen^1,2,10

¹Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ²School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, Netherlands, ⁴Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ⁶Department of Radiology and Radiological sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁷Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, ⁸School for Mental Health & Neuroscience, Maastricht University, Maastricht, Netherlands, ⁹Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, Netherlands, ¹⁰Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Synopsis

Keywords: Neurodegeneration, Neurofluids, Sex differences, Perivascular spaces, Waste clearanceCerebral waste clearance reduces with healthy aging and occurs in various neurodegenerative diseases. Both perivascular spaces (PVS) and the parasagittal dural (PSD) space play important roles in waste clearance, where the former transports waste products through the parenchyma, the latter is associated with cerebrospinal fluid efflux from the cranial compartment. The current 7T MRI study investigated sex differences in the relation between PVS and PSD volume in an elderly sample. By identifying a relationship between PVS and PSD solely in females, this study illustrates the possibility of a different impairment mechanism of the clearance system between elderly men and women.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.