Abstract #1741

Time-dependent diffusion-weighted imaging for differentiation between glioblastoma and brain metastasis

Kiyohisa Kamimura¹, Tsubasa Nakano¹, Tomohito Hasegawa¹, Masanori Nakajo¹, Hiroyuki Uchida², Takashi Iwanaga³, Hiroshi Imai⁴, Thorsten Feiweier⁵, and Takashi Yoshiura¹

¹Radiology, Kagoshima University, Kagoshima, Japan, ²Neurosurgery, Kagoshima University, Kagoshima, Japan, ³Radiological Technology, Kagoshima University Hospital, Kagoshima, Japan, ⁴Siemens Healthcare K.K., Tokyo, Japan, ⁵Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Keywords: Tumors, Diffusion/other diffusion imaging techniquesTo investigate the utility of time-dependent DWI for differentiating between glioblastoma and brain metastasis, 65 patients with glioblastoma and 27 patients with brain metastasis were examined. ADC was not significantly different between the two tumor types neither at a short (7.1ms) nor at a long (44.5ms) diffusion time, whereas the ADC difference (ΔADCmean, ΔADC5, ΔADC95) and ADC change ratio (rADCmean, rADC5, rADC95) were significantly higher in brain metastasis than in glioblastoma. The ΔADCmean showed the best diagnostic performance. The ΔADCmean and rADCmean showed a significant negative correlation with ADC_44.5msmean, but not with extracellular extravascular space volume fraction derived from DCE-MRI.

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