Abstract #1744

Effects of peritumoral T2 hyperintensities in treated gliomas on the quantification of tumour blood flow with arterial spin labeling.

Magdalena Sokolska¹, James K Ruffle², Meetakshi Gupta³, Julia Markus⁴, Michael Kosmin³, Hans Rolf Jäger ², Parashkev Nachev², and Harpreet Harpreet⁴

¹Medical Physics and Biomedical Engineering, University College London Hospitals, London, United Kingdom, ²Queen Square Institute of Neurology, University College London, London, United Kingdom, ³Radiotherapy, University College London Hospitals, London, United Kingdom, ⁴Imaging, University College London Hospitals, London, United Kingdom

Synopsis

Keywords: Tumors, Arterial spin labellingElevated tumour blood flow in treated gliomas t can be indicative of disease recurrence. TBF can be visualised and quantified with arterial spin labelling with quantification performed by scaling a perfusion-weighted image by a proton density image and a brain-blood partition coefficient, assuming mapping to a fully relaxed blood magnetisation signal. However, this assumption might not hold in T2/FLAIR hyperintense areas surrounding enhancing tumour due to much higher water content. Therefore, this work investigates blood flow quantification in three tumour compartments, enabled by recent developments in AI-generated labels of tumour components.

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