Abstract #1746

Pretreatment Apparent Diffusion Coefficient Value for Prediction of Relapsed and Refractory Primary Central Nervous System Lymphoma

Ching-Chung Ko^1,2, Lee-Ren Yeh³, and Jeon-Hor Chen⁴

¹Chi Mei Medical Center, Tainan, Taiwan, ²Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan, ³Department of Radiology, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan, ⁴Department of Radiological Sciences, University of California, Irvine, CA, United States

Synopsis

Keywords: Tumors, CancerA subset of primary central nervous system lymphoma (PCNSL) may show early relapsed/refractory (R/R) disease after treatments. This study investigated the role of pretreatment apparent diffusion coefficient (ADC) values for the prediction of R/R in PCNSL. Total 52 patients with pathologically confirmed PCNSL were included, and 24 (46.2%) patients developed R/R (median time to relapse, 13 months) after treatment. The results showed female sex, complete response to first-line chemotherapy, and ADC value/ratio were significant predictors of R/R in PCNSL. Pretreatment ADC values/ratios offer objective and valuable evaluation for the treatment planning in PCNSL.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.