Abstract #1750

Healthy and cancerous brain ADC: diffusion- and echo time dependence with pulsed gradient spin-echo (PGSE) diffusion imaging

Jens Johansson¹, Kerstin Lagerstrand^2,3, Isabella M Björk-Burtscher^1,4, Mats Laesser^1,5, Hanna Hebelka^1,4, and Stephan E Maier^1,6

¹Radiology, Clinical sciences,Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Medical Radiation Sciences, Clinical sciences,Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ³Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden, ⁴Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden, ⁵Sahlgrenska University Hospital, Gothenburg, Sweden, ⁶Radiology, Brigham and women's hospital, Boston, MA, United States

Synopsis

Keywords: Tumors, Diffusion/other diffusion imaging techniques, Diffusion timeClinical systems vary widely in their gradient performance. Accordingly, effective diffusion time and echo time, which are minimized by the system software according to available gradient performance, can differ significantly among systems. A major concern is that non-Gaussian diffusion in tissues can lead to significant variation of the measured apparent diffusion coefficient (ADC), which would clearly diminish its value as biomarker. This study evaluated if diffusion and/or echo time variations in pulsed gradient spin-echo (PGSE) sequences significantly influences the ADC measured in healthy brain and brain tumors.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.