Abstract #1751

Intravoxel Tissue Heterogeneity Revealed by Non-Gaussian Time-Dependent Diffusion MRI and Its Correlation with Histology

Guangyu Dan^1,2, Weiguo Li^2,3,4, Kaibao Sun¹, Qingfei Luo¹, Muge Karaman^1,2, and Xiaohong Joe Zhou^1,2,5

¹Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States, ²Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, United States, ³Research Resource Center, University of Illinois at Chicago, Chicago, IL, United States, ⁴Department of Radiology, Northwestern University, Evanston, IL, United States, ⁵Departments of Radiology and Neurosurgery, University of Illinois College of Medicine, Chicago, IL, United States

Synopsis

Keywords: Tumors, Tumor, GliomaRecently, diffusion-weighted MRI has emerged for probing intravoxel structural heterogeneity non-invasively as an alternative to gold standard histopathological analysis. A previous study demonstrated the correlation between the imaging- and histology-based tissue heterogeneities using a continuous-time random-walk (CTRW) model at a single diffusion time. In this study, we extended the study to multiple diffusion times and investigated the diffusion time dependence of the CTRW parameters and their correlation with histology-based heterogeneity on human glioma tissues. Significant time dependency was observed in the CTRW parameters, providing practical insights into the selection of diffusion time when assessing tissue heterogeneity.

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