Abstract #1753

Arterial Spin Labeling in Cerebral Gliomas During Breath-Holding

Sergio M. Solis-Barquero^1,2, Marta Calvo-Imirizaldu^1,2, Veronica Aramendia-Vidaurreta^1,2, Rebeca Echeverria-Chasco^1,2, Antonio Martinez-Simon³, Elena Cacho-Asenjo³, Marta Vidorreta⁴, Pablo D. Dominguez^1,2, Reyes Garcia de Eulate¹, and Maria A. Fernandez-Seara^1,2

¹Department of Radiology, Clinica Universidad de Navarra, Pamplona, Spain, ²IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain, ³Department of Anesthesia, Perioperative Medicine and Critical Care, Clinica Universidad de Navarra, Pamplona, Spain, ⁴Siemens Healthcare, Madrid, Spain

Synopsis

Keywords: Tumors, Perfusion, Breath HoldingPCASL was used to measure cerebral blood flow (CBF) in eighteen patients with high-grade gliomas (III and IV) during normal breathing followed by a breath-holding task (ten periods of 21s interleaved with periods of normal breathing) to assess baseline CBF and cerebrovascular reactivity (CVR). All patients completed the task successfully and CBF and CVR maps were generated. CBF ratio in contrast-enhanced tumor area was higher in grade IV than grade III gliomas, as expected. CVR in tumor areas was decreased compared to GM CVR values. More studies are needed to assess the CVR heterogeneity in tumoral tissue.

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