Abstract #1757

Perfusion and Time of Exchange Measurements Using BBB-ASL in Gliomas: The Initial Experience

Gülce Turhan¹, Ayşe İrem Çetin¹, Amnah Mahroo², Beatriz Padrela³, Simon Kanstandin^4,5, Daniel Christopher Hoinkiss², Nora Josefin Breutigam², Klaus Eickel^2,5, Jan Petr⁶, Henk Mutsaerts³, Ayca Ersen Danyeli⁷, Koray Ozduman⁸, Matthias Guenther^2,5, Alp Dincer^9,10, and Esin Ozturk-Isik^1,10

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany, ³Amsterdam University Medical Center, Amsterdam, Netherlands, ⁴Fraunhofer Institute for Digital Medicine MEVI, Bremen, Germany, ⁵mediri GmbH, Heidelberg, Germany, ⁶Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ⁷Department of Pathology, Acibadem University, Istanbul, Turkey, ⁸Department of Neurosurgery, Acibadem University, Istanbul, Turkey, ⁹Department of Radiology, Acibadem University, Istanbul, Turkey, ¹⁰Brain Tumor Research Group, Acibadem University, Istanbul, Turkey

Synopsis

Keywords: Tumors, Arterial spin labellingSubtle changes in BBB integrity might be missed by contrast-enhanced T1-weighted MRI. Blood-brain barrier arterial spin labeling (BBB-ASL) is a new technique to assess BBB disruptions. In this work, we measured the cerebral blood flow (CBF) and exchange time (Tex) values of the tumor, normal-appearing white matter, and normal-appearing gray matter regions in gliomas using BBB-ASL technique. Our results indicated higher CBF and leakier BBB in contrast-enhanced regions of gliomas than in the normal-appearing GM.

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