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Abstract #1778

Improved reliability of R2* and susceptibility quantification using 3D EPI acquisition

Yujia Huang1, Peter van Gelderen2, Lin Chen3,4, Jacco A. de Zwart2, Zeynep Demir2, Gael Saib5, Xu Li3,4, Jeff H. Duyn2, and Jiaen Liu1
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Laboratory of Functional and Molecular Imaging , NINDS, NIH, Bethesda, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 4Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, 5NMR Research Center, NINDS, NIH, Bethesda, MD, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Susceptibility mapping

The quantification of decay rate R2* and susceptibility is useful in assessment of various neurological disorders manifesting iron accumulation and myelin loss. Conventional 3D GRE acquisition is sensitive to motion and B0 fluctuation due to its long scan time. In this study, we demonstrated improved reliability of multi-shot multi-echo 3D EPI when compared to GRE, showing reduced scan time and similar accuracy.

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