Abstract #1779

Zooming In: MR and PET Synaptic Density Imaging Techniques in Neuropathology

Divya Ramakrishnan¹, Takuya Toyonaga², Behnaz Khazai³, Matthew Sala¹, Jason Cai², and Mariam Aboian¹

¹Department of Radiology, Yale School of Medicine, New Haven, CT, United States, ²Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States, ³Department of Radiology, Norwalk Hospital, Norwalk, CT, United States

Synopsis

Keywords: Quantitative Imaging, PET/MR, Synaptic Density, SV2AThere are many different modalities to image synaptic density in the brain. The advent of a novel SV2A targeted PET tracer provides the ability to measure in-vivo synaptic density changes in neuropsychiatric disorders. In this education exhibit, we review the current MR and PET-based approaches to synaptic density imaging and present findings from recent animal and human studies of synaptic density changes in neurodegenerative disorders and epilepsy. Our aim is to provide clinicians with the most up-to-date knowledge about imaging techniques of synaptic density that can be integrated into clinical practice.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.