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Abstract #1782

Characterization of Longitudinal Anatomic and Functional Changes following HIFU Therapy and Implications for Prostate Cancer Surveillance

Adrian Breto1, Ahmad Algohary1, Michael Tradewell2, Leonardo Bittencourt3, Oleksandr Kryvenko4, Mark Gonzalgo2, Sanoj Punnen2, Dipen Parekh2, Bruno Nahar2, and Radka Stoyanova1
1Department of Radiation Oncology, University of Miami, Miami, FL, United States, 2Desai Seth Urology Institute, Miami, FL, United States, 3Department of Radiology, UH Cleveland Medical Center, Cleveland, OH, United States, 4Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL, United States

Synopsis

Keywords: Quantitative Imaging, Prostate, Focused UltrasoundDetecting prostate cancer recurrence after high intensity focused ultrasound (HIFU) therapy is a challenge for clinicians. We characterize longitudinal anatomical/functional changes of prostate in men undergoing HIFU therapy for prostate cancer. Nineteen men had mpMRI exams pre-HIFU, and at 1 and 12 months post-HIFU. Prostate volume decreased by 17% on the one year exam and in two-thirds of men changes in prostatic axis, up to 20 degrees in the direction of ablation. Functional mpMRI analysis shows a dramatic decrease in volume transfer constant (Ktrans) on dynamic contrast enhancing (DCE) imaging while there were no changes in apparent diffusion coefficient (ADC).

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Keywords