Abstract #1784

Automatic Assessment of UTE MRI High Signal Volume in the Lung for Pediatric Patients with Cystic Fibrosis

Daniel Genkin¹, Brandon Zanette², Thomas Benkert³, Felix Ratjen^2,4, Giles Santyr^2,5, and Miranda Kirby⁶

¹Department of Electrical, Computer, and Biomedical Engineering, Toronto Metropolitan University, Toronto, ON, Canada, ²Department of Translational Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ³MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ⁴Department of Pediatrics, University of Toronto, Toronto, ON, Canada, ⁵Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁶Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada

Synopsis

Keywords: Quantitative Imaging, Lung, UTE, CF, PediatricHigh signal volume (MR-HSV) obtained by Ultrashort Echo-Time (UTE) MRI has been shown to be associated with disease severity in adults with CF, but has yet to be investigated in pediatric CF patients. In this study, MR-HSV was automatically extracted from UTE MRI of pediatric CF (n=9) and healthy (n=4) participants. MR-HSV measurements were significantly increased in CF compared to health, and increased MR-HSV correlated with decreased lung function (ie. FEV_1pp, FEV₁/FVC). The findings in this work confirm that MR-HSV measurement is feasible in pediatric participants and may reflect disease severity associated with airway/parenchyma signal intensity abnormalities in CF.

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