Keywords: Quantitative Imaging, CancerThe extended Tofts model (ETM) requires calculation of contrast agent concentration in tissue as function of time (C(t)) using a non-linear model that results in error propagation. Here, we introduce a signal intensity (S(t)) form of ETM (SI-ETM) without calculating C(t). QIBA DCE-MRI data was used to validate the SI-ETM, and then human prostate DCE-MRI data were analyzed to compare physiological parameters calculated from the ETM and the SI-ETM. The parameters calculated from S(t) were strongly correlated with the values calculated from C(t). Bland–Altman analysis showed good agreement between the parameters calculated from the ETM and the SI-ETM.
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