Abstract #1789

Feasibility and clinical implementation of ultra-fast GRAPPATINI T2 mapping of the brain: A prospective study

Natascha Karolina Gruenebach¹, Antoine Sanner¹, Nils Friedrich Grauhan¹, Mario Alberto Abello Mercado¹, Andrea Kronfeld¹, Vanessa Ines Schoeffling¹, Tom Hilbert^2,3,4, Marc A. Brockmann¹, and Ahmed E. Othman¹

¹University medical center Mainz, Mainz, Germany, ²Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ³Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁴LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Synopsis

Keywords: Quantitative Imaging, Relaxometry, T2 Mapping

We aimed to validate the clinical feasibility of the quantitative imaging MR-sequence GRAPPATINI. It offers T2 relaxometry values as well as synthetic T2-weighted images of the whole brain. 10 volunteers for the validation of repeatability and reproducebility on intra- and intersubject level and 52 patients for the morphological comparison between GRAPPATINI and standard T2-weighted sequence were included prospectively. T2 relaxation times of GRAPPATINI are robust and show only little variations among healthy subjects. Larger deviations only were found in caudate nucleus. Moreover its synthetic T2-weighted images achieve good interrater-reliability, although its subjective image quality is not equivalent to standard TSE.

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