Abstract #1795

Feasibility of R2*-based cerebral venous oxygenation mapping using a clinical susceptibility-weighted imaging protocol

Emma Biondetti^1,2, Alessandro Villani^1,2, Alessandra S. Caporale^1,2, Antonio Maria Chiarelli^1,2, Darien Calvo Garcia^1,2, Massimo Caulo^1,2,3, Valentina Tomassini^1,2,4,5, and Richard G. Wise^1,2,5

¹Department of Neuroscience, Imaging and Clinical Sciences, 'G. d’Annunzio University' of Chieti-Pescara, Chieti, Italy, ²Institute for Advanced Biomedical Technologies (ITAB), 'G. d’Annunzio University' of Chieti-Pescara, Chieti, Italy, ³Department of Radiology, 'SS. Annunziata' University Hospital, Chieti, Italy, ⁴MS Centre, Department of Clinical Neurology, 'SS. Annunziata' University Hospital, Chieti, Italy, ⁵Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: Quantitative Imaging, Oxygenation

The brain’s oxygen extraction fraction (OEF) is a key parameter in assessing cerebrovascular function and brain oxygen consumption. We investigated the feasibility of measuring cerebral venous oxygenation (SvO₂), the key determinant of OEF, based on R2* estimated from a clinical susceptibility weighted imaging protocol and vessel segmentation aided by gadolinium administration, in a cohort of patients with Multiple Sclerosis. We were able to estimate venous oxygenation in the superior sagittal sinus, straight sinus, transverse sinuses and internal cerebral veins. The global median SvO₂ ranged between 0.60 and 0.68, within the range of values expected in the human brain.

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