Abstract #1798

Diffusion Tensor Imaging Parameters in ALS Post Mortem In Situ versus Ex Situ MR Acquisitions

Dominique Neuhaus^1,2, Maria Janina Wendebourg^3,4, Eva Scheurer^1,2, Celine Berger^1,2, Melanie Bauer^1,2, Tanja Haas⁵, Regina Schlaeger^3,4, and Claudia Lenz^1,2

¹Institute of Forensic Medicine, Dept. of Biomedical Engineering, University of Basel, Basel, Switzerland, ²Institute of Forensic Medicine, Health Department Basel-Stadt, Basel, Switzerland, ³Neurology Clinic and Polyclinic, Dept. of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland, ⁴Translational Imaging in Neurology (ThINk), Dept. of Biomedical Engineering, University of Basel, Basel, Switzerland, ⁵Division of Radiological Physics, Dept. of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland

Synopsis

Keywords: Quantitative Imaging, Diffusion Tensor ImagingThe development of magnetic resonance imaging (MRI) biomarkers in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) might alleviate current challenges. Generally, post mortem (PM) ex situ quantitative imaging is used for the validation of potential biomarkers, which shows several limitations. In this study, PM MRI brain scans of three deceased ALS patients have been conducted. The objective was to identify differences between in situ and ex situ scans regarding the diffusion tensor imaging (DTI) measures fractional anisotropy (FA) and mean diffusivity (MD). A significant difference was found for the FA values in white matter.

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