Keywords: Quantitative Imaging, ModellingJoint fitting of ADC and R2 improves the noise characteristics of whole-body R2 maps when using an iterative weighted least squares (IWLS) estimation that accounts for the signal offset, ρ, between diffusion-weighted and multi-echo-time imaging sequences. This is demonstrated using simulation experiments using relevant values of R2, ADC, and signal-to-noise ratio (SNR), where we find an improvement in R2 precision using the joint-fitting approach. Initial validation was further performed in clinical imaging examples to demonstrate the improvement in R2 map detail.
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