Abstract #1807

Apparent diffusion coefficient of the lumbar intervertebral disc as a quantitative indicator of disease severity and treatment effectiveness

Daiki Sakamoto¹, Xinnan Li¹, Hiroyuki Hamaguchi¹, Katsuhisa Yamada², Hideki sudo², and Khin Khin Tha^1,3

¹Laboratory for Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Hokkaido, Japan, ²Department of Orthopedic Surgery, Hokkaido University Faculty of Medicine, Hokkaido, Japan, ³Grobal Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Hokkaido, Japan

Synopsis

Keywords: Quantitative Imaging, Degenerative, Intervertebral disc degeneration, ADC, T1rho, T2*, LumbarThis prospective study aimed to evaluate the role of T1ρ, T2*, and ADC – the quantitative MRI indices, in determining the severity of intervertebral disc degeneration and treatment effectiveness. All three indices decreased with increasing Pfirmman grade, which determines the severity, suggestive of their potential as indicators of disease severity. The mean ADC of the degenerated disc increased significantly after surgery, suggesting its potential as a treatment effectiveness indicator.

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