Keywords: Quantitative Imaging, CEST & MTCEST MRI is a promising molecular imaging technique, but the in vivo quantification inherently faces challenges because of multiple types of signal contaminations. Herein we introduced a QUEST-like 10-point fitting method for simultaneous NOE and amide quantification at 3T with reduced T1 contamination. The quantification method was evaluated by simulations and phantom experiments. Furthermore, for glioblastoma patients, the highlighted regions on fitted amide images are consistent with the hyperintensities on Gd-T1W maps, which is a smaller enhanced area than those on conventional APTw images. The initial results on tumor patients indicate its potential for clinical use.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords