Keywords: Liver, Hyperpolarized MR (Non-Gas)Nonalcoholic fatty liver disease and diabetes are known to be closely related, but the mechanism has not been defined yet. The metabolic feature of the diabetic liver is that gluconeogenesis and fatty acid synthesis increase simultaneously. In this study, we hypothesized that ATP citrate lyase (ACLY) would play an essential role in inducing metabolic contradiction in the diabetic liver and investigate ACLY’s role on carbohydrate metabolism using hyperpolarized (HP) 13C pyruvate magnetic resonance spectroscopy (MRS) and primary mouse hepatocytes.
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