Abstract #1839

Accuracy and test-retest repeatability of stiffness measurement with MR Elastography: a multi-center phantom study

Efe Ozkaya^1,2, Paul Kennedy^1,2, Jun Chen³, Octavia Bane^1,2, Jonathan R. Dillman⁴, Kartik S. Jhaveri⁵, Michael Ohliger ^6,7, Phillip J. Rossman³, Jean A. Tkach⁴, Sudhakar K. Venkatesh³, Richard L. Ehman³, and Bachir Taouli^1,2

¹Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Radiology, Mayo Clinic, Rochester, MN, United States, ⁴Department of Radiology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States, ⁵Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital, and Women’s College Hospital,, University of Toronto, Toronto, ON, Canada, ⁶Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ⁷Department of Radiology, Zuckerberg San Francisco General Hospital, San Francisco, CA, United States

Synopsis

Keywords: Liver, Elastography, Phantom, Multicenter study, Accuracy, RepeatabilityThe purpose of our multicenter study was to determine the accuracy and test-retest repeatability of stiffness measured with MRE in phantoms. Three phantoms with known stiffness (2.4, 4.4, and 7.5 kPa) were circulated between 5 different centers. 1.5T or 3T systems from the 3 major vendors were used for scanning with 2D GRE and/or SE-EPI MRE sequences. The reference was based on measurements in the reference center made at the start and end of study. For all 3 phantoms the mean accuracy error for the 4 testing centers was 10.2%, while test-retest repeatability error was 2.9% for all centers.

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