Abstract #1842

Towards Non-Invasive Diagnosis of NASH: Retrospective Fat Correction of MP2RAGE T1 Improves Correlation with Liver Fibrosis Stage

Andrew Duffy¹, Parth Maheta², Andreu F. Costa³, Sharon Clarke^3,4, Ashley Stueck⁵, Magnus McLeod⁶, and James Rioux^2,3,4

¹Medicine, Dalhousie University, Halifax, NS, Canada, ²Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, ³Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, ⁴Biomedical Translational Imaging Centre, Nova Scotia Health Authority, Halifax, NS, Canada, ⁵Pathology, Dalhousie University, Halifax, NS, Canada, ⁶General Internal Medicine, Dalhousie University, Halifax, NS, Canada

Synopsis

Keywords: Liver, Fat, FibrosisThere is significant interest in non-invasive biomarkers for staging of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) to reduce the need for biopsy. T1 correlates with fibrosis but can also be influenced by fat, and while Dixon fat-water separation can remove this effect, such methods are uncommon in clinical T1 mapping sequences. In this work, we demonstrate a retrospective correction to estimate the T1 of liver tissue based on MP2RAGE without fat-water separation. This enables fat compensation in a wider range of acquisitions and improves the potential clinical utility of T1 as a biomarker for liver fibrosis.

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