Abstract #1850

Quantitative Digital Histological Analysis and Comparison to Proton Density Fat Fraction in Patients Undergoing Weight Loss Surgery

Devashish Joshi¹, David Harris², Nikolaos Panagiotopoulos², Danielle Batakis³, Eduardo Grunvald⁴, Xiaofei Zhang⁵, Rashmi Agni⁵, Santiago Horgan⁶, Luke Funk¹, Claude Sirlin³, and Scott Reeder^2,7,8,9,10

¹Surgery, University of Wisconsin - Madison, Madison, WI, United States, ²Radiology, University of Wisconsin - Madison, Madison, WI, United States, ³Radiology, Liver Imaging Group, University of California San Diego, La Jolla, CA, United States, ⁴Medicine, University of California San Diego, La Jolla, CA, United States, ⁵Pathology, University of Wisconsin - Madison, Madison, WI, United States, ⁶Surgery, University of California San Diego, La Jolla, CA, United States, ⁷Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁸Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁹Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ¹⁰Medical Physics, University of Wisconsin - Madison, Madison, WI, United States

Synopsis

Keywords: Liver, Fat

The goal of our study was to correlate quantitative digital microscopic histological markers of hepatic steatosis with MRI-PDFF and demonstrate that microenvironment characterization can be used to evaluate hepatic microstructure in NAFLD for future MRI-based studies. Patients were recruited to undergo weight loss surgery during which a liver biopsy was performed. The biopsies were analyzed for steatosis proportionate area (SPA) and characterization of fat droplets. The SPA strongly correlated to the pathologist grading and MRI-PDFF and the liver fat content strongly correlated with the number of fat droplets. Our work demonstrated the feasibility of using MRI to characterize liver microstructure.

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