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Abstract #1851

Detecting Hepatic Flexibility in patients with Non-Alcoholic Fatty Liver Disease (NAFLD) using 1H Magnetic Resonance Spectroscopy

Dragana Savic1, Ferenc E. Mózes1, Leanne Hodson1, Stefan Neubauer1, Michael Pavlides1, and Ladislav Valkovič1
1University of Oxford, Oxford, United Kingdom

Synopsis

Keywords: Liver, Liver, L-carnitine, acetylcarnitineThis study investigated serum carnitine species and in-vivo hepatic acetylcarnitine levels as measured with MRS in healthy volunteers, and patients with low-risk NAFLD and high-risk NAFLD. L-carnitine facilitates transport of fatty acids into the mitochondria. We show that a single injection of L-carnitine modulated acetylcarnitine levels in the liver in healthy volunteers and low-risk NAFLD, but that this mechanism was blunted in the high-risk NAFLD group. This was accompanied by changed serum medium-chain and long-chain carnitine species, but only in the high-risk NAFLD group. Further studies are needed to understand the plasma and hepatic metabolic changes of carnitine species.

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