Abstract #1852

Effect of isocaloric ketogenic diet on fat content in the liver and muscle and volume of adipose tissue

Petr Sedivy¹, Barbora Setinova¹, Martin Burian¹, Dita Pajuelo¹, Milan Hajek¹, Viktor Sebo², Michal Koc², Michaela Siklova², Marina Henikova², Eva Krauzova³, Jan Gojda², Lenka Rossmeislova², Jan Kovar⁴, and Monika Dezortova¹

¹MR-Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Department of Pathophysiology, Third Faculty of Medicine, Charles University, University Hospital Královské Vinohrady, Prague, Czech Republic, ³Department of Internal Medicine, Third Faculty of Medicine, Charles University, University Hospital Královské Vinohrady, Prague, Czech Republic, ⁴Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

Synopsis

Keywords: Liver, Metabolism, fat fraction, liver steatosis, intra- and extramyocellular fat, calf muscleThe effect of a 28-day isocaloric ketogenic diet followed by a 2-day carbohydrate realimentation on adipose tissue and fat content in the liver and calf muscle in 22 obese women was studied using MRS and MRI methods. During the ketogenic diet, there was a significant decrease in liver fat volume (69±20 ml, i.e. decrease 43±4% of basal value) and liver fat content (2.7±0.6 %, i.e. 35±5% of basal value) and reduction cross-section in both subcutaneous (6 %) and visceral (7 %) fat. Contrary, the intramyocellular fat increased during the diet.

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