Keywords: Liver, Quantitative Imaging, RelaxometryQuantitative parametric mapping is an increasingly important tool for non-invasive assessment of liver disease. The extent of change in both water and fat content in the liver is dependent on the type and stage of the disease. Thus, proton density fat fraction (PDFF%) can have a confounding influence on the longitudinal change in estimated hepatic T1, T2, and T2* measurements. In 14 research participants, T1 was proportionately underestimated (4.70 (2.85, 6.54) ms/PDFF%) and T2 was proportionately overestimated (-0.60 (-0.76, -0.43) ms/PDFF%) with non-fat-suppressed parametric map compared to analogous estimates with fat-suppressed parametric maps, while T2* estimates were insensitive to PDFF.
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