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Abstract #1875

Primary prostate cancer characterisation using internal references for 23Na MRI quantification

Anne Adlung1,2, Fabian Tollens3, Anika Strittmatter1,2, Niklas Westhoff4, Daniel Hausmann5, Stefan O Schoenberg3, Lothar R Schad1,2, Dominik Nörenberg3, and Frank G Zöllner1,2
1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 3Department of Radiology and Nuclear Medicine, Mannheim University Medical Centre, Mannheim, Germany, 4Department of Urology and Urosurgery, Mannheim University Medical Centre, Mannheim, Germany, 5Department of Radiology, Kantonsspital Baden, Baden, Switzerland

Synopsis

Keywords: Prostate, TumorAim of this prospective study was to evaluate 23Na MRI of 36 patients with suspected prostate cancer and quantify tissue sodium concentration (TSC) based on internal references. TSC reference regions were defined within both femoral blood vessels (FBV), where TSC showed no significant differences between both sides (3.3±2.2 mM, p=0.076). TSC in the prostate was 39.0±5.3 mM; significantly higher in the peripheral than in the transitional zone (p=0.0004, mean difference 4.7±3.5 mM). Nine lesions were segmented and showed mean TSC of 32.2±5.5, significantly lower than contralateral (p=0.0181). TSC might represent a quantitative biomarker that could improve prostate lesion characterization.

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