Abstract #1901

Structural and Neuroradiological Findings in COVID-19 Patients with Post-COVID Neurological Symptoms with Ultrahigh Field 7T MRI

Shams Rashid^1,2, Oleksandr Khegai¹, Nathalie Jette³, Puneet Belani¹, Puneet Pawha¹, Sera Saju¹, Ameen Al Qadi¹, Allison Navis³, Brian Mathew³, Jonathan Goldstein³, Kapil Gururangan³, Qing Hao³, Anuradha Singh³, Jacqueline Becker⁴, Bradley Delman¹, and Priti Balchandani^1,2

¹Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Keywords: Infectious disease, COVID-19, Ultrahigh Field, hippocampal subfields, amygdala subnucleiWe present preliminary findings of neuroradiological analysis and FreeSurfer-based cortical segmentation analysis which show changes in deep gray matter structures from ultrahigh field MR neuroimaging at 7T in patients with post-COVID neurological symptoms. 8 hippocampal subfields and 4 amygdala subnuclei had significantly increased volume in a cohort of 12 COVID-19 patients with post-COVID neurological symptoms compared to matched healthy controls. These changes may indicate neuroinflammation of the hippocampus and amygdala in COVID-19, which may be related to the neurological symptoms of memory impairment, “brain fog” and anxiety in our COVID patient cohort.

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