Keywords: Brain Connectivity, COVID-19The neural mechanisms underlying the neuropsychiatric disorders suffered by Long-Covid-19 patients remain unknown. Non-invasive [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) brain imaging is an effective way to study this issue. In the present study, based on 18F-FDG PET brain imaging and analysis of the brain metabolic network, we found significant reductions in metabolic levels in the frontal, temporal, and parietal lobes in patients with Long-Covid-19. A significant reduction in metabolic connectivity between temporal and frontal networks in patients with Long-Covid-19 may be the underlying neural mechanism underlying cognitive impairment.
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