Abstract #1909

Frontal-specific elevation of cerebral oxygen extraction fraction in COVID-19 ICU survivors: a pilot study

Dengrong Jiang¹, Hannah Rando², Shivalika Khanduja², Jie Song³, Kaisha Hazel¹, George Pottanat¹, Ebony Jones¹, Cuimei Xu¹, Wen Shi⁴, Zhiyi Hu⁴, Doris Lin¹, Sevil Yasar⁵, Sung-Min Cho², and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University School of Engineering, Baltimore, MD, United States, ⁴Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Infectious disease, COVID-19Compared to patients with mild COVID-19 disease, critically ill patients requiring intensive-care-unit (ICU) admission are at higher risk of developing post-acute COVID-19 syndrome (PCS). The mechanisms underlying PCS are under investigation and may involve neurovascular damage, which can disrupt oxygen delivery and utilization in the brain. Cerebral oxygen-extraction-fraction (OEF) is an important parameter for the brain’s oxygen utilization. In this work, we evaluated the post-acute changes of regional OEF in COVID-19 ICU-survivors, and found that ICU-survivors had significantly increased OEF in the frontal lobe compared to controls. This suggests that regional OEF may provide a sensitive biomarker in studying PCS.

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