Abstract #1913

Investigating the effects of Long COVID on cerebrovascular reactivity using VASO at 3T

Sharyfah Alasiri^1,2, Elisa Zamboni^2,3, Isaac Watson^2,4, Heather Owston⁵, Heidi Baseler^3,6, Dennis McGonagle⁷, and Aneurin Kennerley^2,8

¹Biomedical Sciences, University of York, York, United Kingdom, ²York Neuroimaging Centre, University of York, York, United Kingdom, ³Psychology, University of York, York, United Kingdom, ⁴School of Physics, Engineering, and Technology, University of York, York, United Kingdom, ⁵Medical and Biological Engineering, University of Leeds, Leeds, United Kingdom, ⁶Hull York Medical School, University of York, York, United Kingdom, ⁷School of Medicine, University of Leeds, Leeds, United Kingdom, ⁸Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom

Synopsis

Keywords: Blood vessels, COVID-19, cerebrovascular reactivityStrategies to help sufferers from Long COVID (LC) mostly focus on symptoms management. There is an urgent need for understanding whether and how the cerebrovascular system is implicated in emergent symptoms. Here we use advanced cerebral blood volume (CBV)-based imaging techniques to appropriately quantify changes in vascular reactivity in patients affected by LC compared to healthy volunteers. A slower vasodilation mechanisms, leading to inappropriate oxygen supply during neuronal function, could be used as biomarker and help clinical diagnosis.

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