Keywords: Lung, LungDisruption to pulmonary perfusion is seen in several diseases, with most work focusing on the first-pass to calculate metrics of pulmonary blood volume and flow and mean transit time. The additional information from the leakage-phase acquisition has shown utility in multiple organs but it is less commonly used in the lung. This work aimed to assess the differences between fitting data with and without the first-pass bolus to estimate the volume transfer constant and fractions of blood in the extravascular-extracellular space and plasma in a multicentre setting.
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