Abstract #1915

Leakage phase perfusion in healthy volunteers and subjects post-COVID-19: results from the C-MORE study

Paul John Clifford Hughes¹, Laura Saunders¹, Louise V Wain^2,3, Christopher E Brightling², Stefan Neubauer^4,5, Betty Raman⁴, C-MORE/PHOSP-COVID Collaborative Group⁶, and Jim Wild¹

¹POLARIS, University of Sheffield MRI Unit, IICD, The University of Sheffield, Sheffield, United Kingdom, ²Institute for Lung Health, Leicester NIHR Biomedical Research Centre, University of Leicester, Leicester, United Kingdom, ³Department of Health Sciences, University of Leicester, Leicester, United Kingdom, ⁴Division of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), University of Oxford, Oxford, United Kingdom, ⁵Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁶Full group details can be found in Appendix 1 of, https://doi.org/10.1016/S2213-2600(21)00383-0, London, United Kingdom

Synopsis

Keywords: Lung, LungDisruption to pulmonary perfusion is seen in several diseases, with most work focusing on the first-pass to calculate metrics of pulmonary blood volume and flow and mean transit time. The additional information from the leakage-phase acquisition has shown utility in multiple organs but it is less commonly used in the lung. This work aimed to assess the differences between fitting data with and without the first-pass bolus to estimate the volume transfer constant and fractions of blood in the extravascular-extracellular space and plasma in a multicentre setting.

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