Abstract #1916

Single-shell diffusion MRI for imaging white-matter microstructure in COVID-19: DTI vs. correlated diffusion imaging

Nick Teller¹, Jordan A. Chad^1,2, Alexander Wong³, Hayden Gunraj³, Xiang Ji⁴, Bradley J. MacIntosh^2,4, Asaf Gilboa^1,5, Eugenie Roudaia¹, Allison B. Sekuler^1,5, Benjamin Lam⁴, Chris Heyn⁴, Sandra E. Black⁴, Simon J. Graham^2,4, and J. Jean Chen^1,2,6

¹Rotman Research Institute, North York, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Department of System Design Engineering, University of Waterloo, Waterloo, ON, Canada, ⁴Sunnybrook Research Institute, Sunnybrook Health Science Centre, Toronto, ON, Canada, ⁵Department of Psychology, University of Toronto, Toronto, ON, Canada, ⁶Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Data Analysis, Diffusion/other diffusion imaging techniques, Correlated diffusion imaging, single-shell diffusion MRI.This study examines microstructural white-matter differences between self-isolated COVID-19 patients and controls using correlated diffusion (CDI) and diffusion-tensor imaging (DTI) based on single-shell acquisitions. Correlated diffusion imaging reveals microstructural differences between patients and controls in frontal, olfactory, and cerebellar regions previously unseen with diffusion-tensor imaging. Our results suggest CDI as a feasible single-shell imaging technique that is sensitive to distinct impacts in various brain regions.

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